Data Category pdbx_reference_molecule_details
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General 
- Category name
- pdbx_reference_molecule_details
- Required in PDB entries
- no
- Category group membership
- bird_family_dictionary_group pdbx_group
- Used in current PDB entries
- No
Category Relationship Diagrams 
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Category Description
Data items in the PDBX_REFERENCE_MOLECULE_DETAILS category records textual details about small polymer molecules.
Category Example
loop_ _pdbx_reference_molecule_details.family_prd_id _pdbx_reference_molecule_details.prd_id _pdbx_reference_molecule_details.ordinal _pdbx_reference_molecule_details.source _pdbx_reference_molecule_details.source_id _pdbx_reference_molecule_details.text FAM_000001 PRD_000001 1 Wikipedia ? ; Actinomycin D is primarily used as an investigative tool in cell biology to inhibit transcription. It does this by binding DNA at the transcription initiation complex and preventing elongation by RNA polymerase. Because it can bind DNA duplexes, it can also interfere with DNA replication, although other chemicals such as hydroxyurea are better suited for use in the laboratory as inhibitors of DNA synthesis. ; FAM_000001 PRD_000001 2 DrugBank ? ; A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. ; FAM_000001 PRD_000003 3 DOI "DOI:10.1016/S0960-894X(98)00345-X" ; Actinomycin D, C2 and VII, cyclic peptides, inhibit Grb2 SH2 domain association with a phosphotyrosine containing peptide derived from the Shc protein (pTyr317). Actinomycins are the first examples of nonphosphorylated natural ligands of SH2 domain. ;
